You might find that you need to change your HIV treatment at some point. If this happens, your doctor will explain the reasons for this and discuss your treatment options with you.
There may be a problem with the drugs you’re currently on if:
In these circumstances, there is probably a better combination available – in other words, one that will suit you better and give you better results. Your doctor will know the best alternative combination for your situation.
Now more than ever, it is essential that you talk honestly with your doctor about any problems you’ve had with taking your drugs at the right time. If your doctor understands your lifestyle, it’ll be easier to choose a combination that is not too difficult to take.
Don't be worried about being frank with your doctor - they will not be shocked by, or judgemental about, anything you tell them - whether it's about using recreational drugs or the type of sex you're having. The more honest you are, the easier it will be for them to prescribe you the right combination.
If you have developed resistance to your antiretrovirals, your doctor will need to look at your treatment history and the results of a test for drug resistance to decide the most suitable combination of drugs for you to take.
There are now a number of anti-HIV drugs that work against virus that is resistant to other drugs.
The recommended options for people who are resistant to the three main classes of drugs - NRTIs, NNRTIs and protease inhibitors - are as follows:
These drugs are most effective when used in combination with another drug which is active against HIV. You doctor will look at your previous drug history and do a resistance test to find out which would work best for you.
If you are resistant to only one class of drugs, the options may be slightly different and your doctor will advise you.
Next: Interactions of HIV treatment with other drugs ››
‹‹ Back to: Resistance to HIV drugs
(3 votes cast)
Please log in
or register to vote.
to add this article to My favourites.
Adding an article to My favourites will allow you to easily come back to it later or print it.
This article was last reviewed on
by Anna Peters
Date due for the next review: 20/11/2018
Content Author: Kerri Virani
Current Owner: Kerri Virani
Anti-HIV drugs, Edited by Greta Hughson, NAM, Aidsmap, 2014
BHIVA guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2015, Writing Group: Duncan Churchill Chair Laura Waters Vice Chair
N Ahmed, B Angus, M Boffito, M Bower, D Dunn, S Edwards, C Emerson, S Fidler, †M Fisher, R Horne, S Khoo, C Leen, N Mackie, N Marshall, F Monteiro, M Nelson, C Orkin, A Palfreeman, S Pett, A Phillips, F Post, A Pozniak, I Reeves, C Sabin, R Trevelion, J Walsh, E Wilkins, I Williams, A Winston
No one with an undetectable viral load, gay or heterosexual, transmits HIV in first two years of PARTNER study, NAM, Aidsmap, Gus Cairns, 4/3/14
START trial finds that early treatment improves outcomes for people with HIV, NAM, Aidsmap, Gus Cairns, 27/5/15
New British guidelines recommend treatment for everyone living with HIV, NAM, Aidsmap, Keith Alcorn, 24/6/15
START trial provides definitive evidence of the benefits of early HIV treatment, NAM, Aidsmap, Liz Highleyman, Produced in collaboration with hivandhepatitis.com, 21/7/15
Various people talk about their experiences of living with HIV.
CAB - Citizens Advice Bureau
HIV Drug Interactions
George House Trust
Equality and Human Rights Commission
Copyright 2018 © Terrence Higgins Trust is a registered charity in England and Wales (reg. no. 288527)
Company reg. no. 1778149 and a registered charity in Scotland (reg. no. SC039986). Registered office: 314-320 Gray's Inn Road, London, WC1X 8DP.