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Odefsey (rilpivirine + emtricitabine + tenofovir alafenamide)


Generic name: Odefsey is a combination of the drugs rilpivirine, emtricitabine and tenofovir alafenamide.

Brand names: Odefsey

Class: Complete combination tablets


Common: Depression, insomnia, headache, nausea.

Rare: Lactic acidosis, serious liver problems (the first two are most likely in very overweight women or those who have been taking Odesfey or similar medicines for a long time), worsening of hepatitis B when stopping Odefsey (see Notes), severe skin rash, body fat redistribution, immune reconstitution inflammatory syndrome (IRIS), renal impairment, decrease in bone mineral density, mineralisation defects.


Tablets comprise 25mg rilpivirine, 200mg emtricitabine and 25mg tenofovir alafenamide (TAF).

Take one tablet once per day.


Odefsey is taken with food.

Odefsey is for people:

  • who have never taken HIV medication before and have a viral load of less than 100,000 copies/mL, or
  • who are changing treatment and meet particular criteria including having an undetectable viral load for six months or longer.

If you're taking Odefsey, do not take St John’s Wort (the herbal supplement).

*Last reviewed on 2/12/2016. Next review: 2/12/2019

Any questions? Email feedback@tht.org.uk Information included on this website was correct at the time of publication.

Data and image supplied by NAM.

Further information on this drug from NAM