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Combivir (lamivudine + zidovudine)


Generic name: lamivudine and zidovudine, sometimes also called 3TC and AZT respectively.

Lamivudine / zidovudine is available as a generic medicine, so its appearance will depend on which type your clinic buys.

Brand names: Combivir (the image on this page is of the version of lamivudine and zidovudine combination which has the brand name Combivir)

Class: Combined NRTI (nukes) tablets


Very common (affecting more than 1 in 10 people): Headache, nausea.

Common (affecting up to 1 in 10 people): Headache, nausea, vomiting, stomach pain, appetite loss, diarrhoea, fever, insomnia, tiredness, joint pain, rash, cough, alopecia, dizziness, feeling unwell, muscle pain, runny nose, anaemia, low white blood cell count (neutropenia or leucopenia), increase in liver enzymes, increased levels of bilirubin.

Uncommon (affecting up to 1 in 100 people): Itching, flatulence, muscle weakness, feeling breathless, thrombocytopenia (decreased levels of cells involved in blood clotting). Decrease in all kinds of blood cells (pancytopenia).


Tablet comprises 150mg lamivudine and 300mg zidovudine.

Take one tablet twice a day.


Take with or without food.

Combivir is no longer recommended as a first choice of treatment for those starting treatment in the UK or USA.

*Last reviewed on 19/12/2016 Next review: 19/12/2019

Any questions? Email feedback@tht.org.uk Information included on this website was correct at the time of publication.

Data and image supplied by NAM.

Further information on this drug from NAM