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Trizivir (lamivudine + zidovudine + abacavir)

Trizivir

Generic name: Trizivir is a combination of the drugs abacavir, lamivudine (sometimes known as 3TC) and zidovudine (sometimes known as AZT).

Brand names: Trizivir

Class: Combined NRTI (nukes) tablets

Side-effects:

For abacavir:


Common: Rash, nausea, vomiting, diarrhoea, fever, headache, tiredness, loss of appetite.


Rare: Hypersensitivity reaction, lactic acidosis, pancreatitis.


For lamivudine:


Common: nausea, vomiting, diarrhoea, headache, stomach pain, hair loss, fever, general feeling of being unwell, insomnia (difficulty sleeping), rash, tiredness, runny nose, cough, joint and muscle pain.


Rare: anaemia (a low red blood cell count), neutropenia (a low white blood cell count), thrombocytopenia (a decrease in the number of cells involved in blood clotting), an increase in liver enzymes. These side-effects would show up in blood tests. Other rare side-effects include an allergic reaction, lactic acidosis, pancreatitis and liver problems.


For zidovudine:


Common: Nausea, vomiting, diarrhoea, stomach pain, headache, dizziness, muscle pain, generally feeling unwell, anaemia (low red blood cell count), neutropenia or leucopenia (low white blood cell count), increase in liver enzymes, increase in bilirubin, rash, fever, breathlessness, flatulence, weakness.


Rare: blood disorders, lactic acidosis, insomnia (difficulty sleeping), liver problems, pancreatitis, chest pain, fits, depression, anxiety, taste disturbance, pins and needles.

Dosage:

Tablet comprises 300mg abacavir, 150mg lamivudine and 300mg zidovudine.

Take one tablet twice a day.

Notes:

Take with or without food.

If you are planning to take abacavir, your doctor should carry out a blood test for a gene called HLA-B*5701. You are more likely to have a hypersensitivity reaction to abacavir if you have this gene. If the test shows that you do have the gene, you should not take abacavir.


*Last reviewed on 25/09/2015 Next review: 25/09/2018

Any questions? Email feedback@tht.org.uk Information included on this website was correct at the time of publication.

Data and image supplied by NAM.

Further information on this drug from NAM