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Q and A with Dr Michael Brady

Dr Michael Brady

‘Undetectable viral load’ and the risk of sexual HIV transmission.

Our knowledge of viral load and HIV transmission has evolved over the years as more robust scientific evidence has developed, and we can now say with more confidence than ever that people on effective treatment cannot pass on HIV.

Here, Dr Michael Brady, Medical Director of Terrence Higgins Trust, answers the most commonly asked questions about being ‘undetectable’ and what this means for HIV transmission.

What is the risk of HIV being passed on when you’re undetectable?

Our message is clear. People on effective HIV treatment cannot pass on the virus. 

That’s because HIV medication (antiretroviral treatment, or ART) works by reducing the amount of the virus in the blood to ‘undetectable’ levels. This means the levels of HIV are so low that the virus cannot be passed on. This is called having an ‘undetectable viral load’.

It can take up to six months for some people to become undetectable from when they start treatment.

What is ‘effective treatment’?

We are using the term ‘effective treatment’ to mean that someone is on treatment, taking it as prescribed and has what we call an ‘undetectable viral load’. In the UK this is usually classed as a viral load below 20 copies/ml.

The Partners PrEP study found that there remains a transmission risk within the first six months of treatment as the HIV positive partner’s viral load takes time to come down.

Therefore ‘effective treatment’ means someone has been taking it as prescribed for at least six months and has an undetectable viral load.

Over 90% of people diagnosed with HIV in the UK are on effective treatment and ‘undetectable’, and therefore they are not infectious.

What is the evidence for this?

Scientific evidence has been building over the last 20 years that demonstrates that the likelihood of HIV transmission is mostly determined by ‘viral load’ (the amount of the virus in the blood or genital tract).

Then, with the publication of last year’s PARTNER study findings in July 2016, we now know enough to be more definitive.

The PARTNER study looked at 888 gay and straight couples (and 58,000 sex acts) where one partner was HIV positive and on effective treatment and one was HIV negative. Results found that where the HIV positive partner had an undetectable viral load, there were no cases of HIV transmission, whether they had anal or vaginal sex without a condom. The PARTNER study looked at couples where the HIV positive partner had a viral load below 200. An undetectable viral load is usually classed as being below 20 copies/ml in the UK.

This is the most robust evidence to date and gives us the evidence we need to say, with confidence, that people on effective treatment cannot pass on HIV.

How sure can we be?

At Terrence Higgins Trust the quality of our health promotion material is very important to us and we do not come to our medical positions lightly. We are members of the Information Standard and ensure that all health information is evidence based, peer reviewed and user tested.

With any scientific study, it is impossible to conduct the research on everybody and therefore a randomised representative sample is studied. The larger the sample size the more likely the results of the study reflect what would happen in real life.

Therefore there has to come a point where we assess the scientific evidence and clinical experience and judge that we know enough to draw a definitive conclusion. In this case, the PARTNER study is large and robust enough that there is now growing consensus among the HIV community that if someone is on effective HIV treatment they cannot pass on HIV. It can take up to six months for some people to become undetectable from when they start treatment.

This has been confirmed by the principal investigators of each of the leading studies that examined this issue, and 240 HIV organisations across the world.

Is this a cure for HIV?

Being ‘undetectable’ is not a cure, as the virus is still present. But effective treatment does mean that you can have a normal life expectancy and cannot pass on the virus to others, so it means there is no reason why HIV should stop you living, working, dating or starting a family as with anyone else.

How variable is an ‘undetectable’ viral load? Can this change over time?
 
HIV specialists have decades of experience managing antiretroviral therapy and we are confident that if someone is taking their medication every day as prescribed, and they are having their viral load checked regularly, they will remain uninfectious.

The presence of other sexually transmitted infections (STIs) can potentially affect viral load, but in the PARTNER study there were no HIV transmissions even when other STIs were present.

It is however important to remember that HIV treatment can only be successful if you have access to it and are taking it as prescribed. 

Stigma can be a barrier to people accessing treatment, and that’s why this message is so important - it will help encourage adherence to medication. We know that if you take effective HIV treatment as prescribed and have an undetectable viral load, you cannot pass on HIV.

If someone’s ability to take their tablets every day changes for any reason (for example due to changes to circumstances or lifestyle) this of course no longer applies and there could be a risk of transmission.

We would always advise that if you are having any problems taking your medication, for any reason, then you discuss that as soon as possible with your HIV doctor or nurses.

Why are we getting this message out?

The fact that being on effective HIV treatment prevents you from passing on the virus is one of the biggest developments to our knowledge of HIV for over 20 years. As the UK’s HIV and sexual health charity, it is vital for us to share this for two reasons.

Firstly, to dispel the stigma, discrimination and myths that so many people living with HIV face on a daily basis. People living with HIV are often ostracised and discriminated against, even by their employers and healthcare professionals, for fear that they are infectious. If everybody knew that people on effective HIV treatment cannot pass on the virus, we could end this stigma.

Secondly, sharing this message will bring down HIV transmissions by encouraging more people to test for HIV and to accept treatment. We know many people still avoid getting tested for fear of the result and because of misconceptions about what the virus means – for example in terms of their health, relationships, employment and family life.

The knowledge that getting onto treatment means you can live a long healthy life without fear of passing on the virus will reduce these barriers. The more people who are encouraged to get tested and onto effective HIV treatment, the fewer HIV infections will happen. This is already being seen in the significant reductions in HIV diagnoses in London sexual health clinics and across all clinics in England.

Does this message promote condomless sex?

In our experience, being ‘undetectable’ does not mean people completely stop using condoms. While being on effective treatment means you cannot pass on HIV, condoms are of course the best way to prevent other STIs and remain, for many people, their preferred way for preventing HIV transmission.

In fact, our service users often tell us that being uninfectious makes it easier for them to have open discussions with new partners about their HIV status and talk about sexual health more generally. What this knowledge does do is to give confidence to people living with HIV who want to date, start a family and have a happy, healthy sex life without fear of passing HIV on to their partners.

If the person living with HIV is on effective treatment and has an undetectable viral load, and both partners have had full sexual health screenings to check for other STIs, as with any other couple, there is no reason they need to continue using condoms if they do not wish to. However, before deciding to stop using condoms, it is a good idea to speak to your HIV doctor or nurse to make sure your viral load is undetectable.

Back to the campaign

 


The Information Standard: Certified member

This article was last reviewed on 26/6/2017 by

Date due for the next review: 26/6/2020

Content Author: Dr Michael Brady

Current Owner: Emily Rosselli

More information:

References

  • Gray et al Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. The Lancet Volume 357, No. 9263, p1149–1153, 14 April 2001
  • In January 2008 the Swiss National AIDS Commission issued what was subsequently to be known as 'The Swiss Statement' stating that: ‘An HIV-infected person on antiretroviral therapy with completely suppressed viraemia (“effective ART”) for over six months and with no STIs is not sexually infectious, ie, cannot transmit HIV through sexual contact.’
  • Cohen et al Antiretroviral Therapy for the Prevention of HIV-1 Transmission N Engl J Med 2016; 375:830-839
  • Rodger et al for the PARTNER study group. Sexual activity without condoms and risk of HIV transmission in serodifferent couples when the HIV-positive partner is using suppressive antiretroviral therapy. JAMA, 2016;316(2):1-11
  • Partners PrEP Study:
    www.ncbi.nlm.nih.gov/pubmed/27070123
    National Center for Biotechnology Information
    US National Library of Medicine
    HIV Transmission Risk Persists During the First 6 Months of Antiretroviral Therapy.
    Mujugira A, Celum C, Coombs RW, Campbell JD, Ndase P, Ronald A, Were E, Bukusi EA, Mugo N, Kiarie J, Baeten JM; Partners PrEP Study Team
    Aug 15 2016;72(5):579-84. doi: 10.1097/QAI.0000000000001019
  • HPTN 052 Study:
    www.ncbi.nlm.nih.gov/pubmed/22227585
    National Center for Biotechnology Information
    US National Library of Medicine
    HIV treatment as prevention and HPTN 052
    Cohen MS, McCauley M, Gamble TR
Can't pass it on

People on effective treatment can't pass on HIV

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