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What PEP is

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PEP (sometimes called PEPSE) is a combination of HIV drugs that can stop the virus taking hold. It can be used after the event if you've put yourself a risk of HIV transmission.

To work, PEP must be taken within 72 hours (three days), and ideally should be taken within 24 hours.

PEP is not a ‘morning after pill’ for HIV, and it’s not guaranteed to work. It’s meant as an emergency measure to be used as a last resort, such as if a condom fails during sex. Taking PEP will not protect you from other sexually transmitted infections or unwanted pregnancy.

Where to get PEP

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PEP is available on the NHS for free, but is only given to people who meet guidelines about its use.

The best place to get PEP is a sexual health or HIV clinic. If you need PEP over the weekend or outside of office hours, when clinics will often be closed, the best place to go is an Accident and Emergency department.

PEP is not normally available from GPs.

Find out your nearest clinic.

As PEP is a powerful course of drugs, and is expensive to prescribe, you might be asked about:

  • the person you had sex with (and the chances that they had HIV)
  • what sort of sex you had (vaginal, oral or anal)
  • if the other person had HIV, what their viral load is.

If the person you had sex with is living with HIV and has had an undetectable viral load, you will not need PEP as it won’t be possible for the virus to have been transmitted.

Once a doctor decides that it’s appropriate for you to have PEP, you will be asked to take an HIV test. This is to make sure you don’t already have HIV. If HIV is detected by a test, other forms of treatment will be recommended to you.

Problems accessing PEP

Sometimes people find it hard to access PEP, and medical staff or receptionists may give out wrong information such as ‘PEP is not available to the general public’.

If this happens, ask to speak to the ‘on-call HIV doctor’ who will know about PEP. You could also try a different hospital.

How to take PEP

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PEP must be taken exactly as instructed and for 28 days. 

  • Do not skip a dose or fail to complete the full month as this makes it less likely to work.
  • Do not double a dose if you miss one.
  • If you do miss a dose and you remember in less than 24 hours, take the next one as soon as you remember.
  • If you miss more than 48 hours of PEP it will be discontinued.

The medication now used for PEP is a single tablet called Truvada and two tablets of raltegravir. 

Side effects from PEP are likely to be mild ones in the first few days, such as nausea, headaches or tiredness.

Do not take recreational drugs while on PEP as there can be dangerous interactions.

Find out if you need PEP

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Take our online risk assessment to find out whether you have taken a risk and whether it’s suitable for to take PEP.

You can also call THT Direct on 0808 802 1221.